Understanding Stem Cell Exhaustion in Aging
Genomic Instability as A Driver of Stem Cell Exhaustion
This project explores how changes in our cells' genetic material contribute to the aging process and the decline of stem cell function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11112344 on NIH RePORTER |
What this research studies
As we age, our body's stem cells become less effective, which can lead to a decline in how well our tissues repair themselves. This project looks at how damage to the genetic material within these stem cells might be a key reason for this decline. Researchers are focusing on muscle stem cells to understand why they lose their ability to repair muscle as we get older. They are also exploring ways to boost a protective protein called p53, which could help these aged stem cells work better.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals experiencing age-related decline in tissue function.
Not a fit: Patients not experiencing age-related tissue decline or those with conditions unrelated to stem cell exhaustion may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to rejuvenate tissues and potentially slow down or reverse some aspects of aging.
How similar studies have performed: While the specific molecular mechanisms are still being uncovered, other studies have shown that restoring stem cell function can improve aged tissues.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rando, Thomas a. — University of California Los Angeles
- Study coordinator: Rando, Thomas a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.