Understanding Spinocerebellar Ataxia Type 5

Who could benefit from this research

What this research studies

Spinocerebellar ataxia type 5 (SCA5) is a brain disorder that causes problems with balance and movement, and currently has no cure. This condition happens because of changes in a gene that makes a protein called "beta-III-spectrin," which is crucial for healthy brain cell connections. We know that these gene changes cause the beta-III-spectrin protein to bind too tightly to another protein called actin, which then harms the development of important brain cells. Our goal is to uncover the exact steps of how this abnormal binding leads to cell damage and the symptoms of SCA5. By understanding these basic mechanisms, we hope to identify new targets for future treatments.

Why it matters

Where this research is happening

• Oakland University
  Rochester, United States Active

Researchers

• Principal investigator: Avery, Adam — Oakland University
• Study coordinator: Avery, Adam

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.