Understanding spinal inflammation in axial psoriatic arthritis
Official title: Characterization of Spinal Pathology in Axial Psoriatic Arthritis
Funded at University of California at Davis · NIH-11048004 · Data updated 2026-11-12
This study is looking at how inflammation affects the spine in people with axial psoriatic arthritis, using special imaging techniques to get a clearer picture of what's happening, which could help doctors diagnose and treat this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $239,488 |
| NIH project number | 1R01AR085314-01 |
| Project ID | NIH-11048004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with axial psoriatic arthritis who experience spinal involvement.
✕Less likely to help
Patients without axial involvement of psoriatic arthritis or those with other forms of arthritis may not benefit from this research.
What this research studies
This research investigates the nature of spinal inflammation in patients with axial psoriatic arthritis (AxPsA), a condition that often goes misdiagnosed. By utilizing advanced imaging techniques like total-body PET/CT, the study aims to visualize and quantify the inflammation in soft tissues associated with the spine, which are typically difficult to assess with standard imaging methods. The research will explore how these imaging findings correlate with the overall inflammatory burden in the spine, potentially leading to improved diagnostic accuracy and treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and management of axial psoriatic arthritis, improving patient outcomes.
How similar studies have gone: Preliminary studies using similar imaging technology have shown promising results in visualizing spinal inflammation in psoriatic arthritis, indicating potential for success in this research.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Chaudhari, Abhijit J — University of California at Davis
- Study coordinator: Chaudhari, Abhijit J
Related research
Other NIH-funded projects on the same topics.
-
Precision monitoring of Psoriatic Arthritis treatment using at-home RNA sampling and smartphone data
A new study will track how Psoriatic Arthritis patients respond to TNF-inhibitor therapy using at-home RNA sampling and a remote smartphone app to collect data.
-
Spine inflammation in psoriatic arthritis
We will use a new total-body PET/CT scan with an FDG tracer to find and measure spinal inflammation in people with psoriatic arthritis that affects the spine.
-
Investigating how IL-17A contributes to psoriatic arthritis
This study is looking at how a protein called IL-17A contributes to psoriatic arthritis, which causes joint pain and inflammation, using a special animal model to find new ways to help people with this condition feel better.
-
Improving Treatment Monitoring for Early Psoriatic Arthritis
This project aims to find better ways to track how well treatments work for people with early psoriatic arthritis by using at-home RNA samples and smartphone data.
-
Understanding the causes of ongoing joint pain in people with psoriatic arthritis
This study is looking at what causes ongoing joint pain in people with psoriatic arthritis, using special imaging techniques to better understand both the physical and emotional aspects of pain, with the goal of finding better ways to help manage it.
-
Understanding how different traits and genes affect treatment responses in psoriatic arthritis
This study is looking at how different traits and genes in people with psoriatic arthritis can affect how well treatments work for them, so we can find better, personalized options for managing their condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.