Understanding Spinal Column Formation to Prevent Birth Defects
A Cross-scale analysis of cell-ECM adhesion in early spinal column development
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11164484
This project explores how cells stick together during early development to understand and prevent spinal column birth defects like spina bifida and scoliosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11164484 on ClinicalTrials.gov |
What this research studies
Our spinal column forms very early in development, and problems during this time can lead to serious birth defects. This project uses zebrafish to closely watch how cells and tissues interact and stick together as the spinal column takes shape. We are particularly interested in how a protein called Fibronectin acts like a glue, influencing both the proper closing of the neural tube and the symmetrical formation of the spine. By understanding these tiny mechanical forces, we hope to learn why defects like spina bifida and scoliosis occur.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical applications could benefit individuals at risk for or affected by spina bifida and congenital scoliosis.
Not a fit: Patients currently living with established spinal column birth defects would not directly benefit from this early-stage developmental research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the causes of spinal birth defects, potentially guiding future strategies for prevention or early intervention.
How similar studies have performed: The lab has recently made discoveries about inter-tissue adhesion in spinal column development, and this project builds upon those initial findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLLEY, SCOTT A — YALE UNIVERSITY
- Study coordinator: HOLLEY, SCOTT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.