Understanding special stem cells in colorectal cancer
Official title: Functional and molecular characterization of Oncofetal Stem Cells in CRC
Funded at Icahn School of Medicine at Mount Sinai · NIH-10942200 · Data updated 2026-11-12
This study is looking at special cells in colorectal cancer to understand how they help tumors grow and resist treatment, with the hope of finding new ways to improve care for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $560,297 |
| NIH project number | 1R01CA292376-01 |
| Project ID | NIH-10942200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with advanced disease or treatment-resistant cases.
✕Less likely to help
Patients with early-stage colorectal cancer or those without a diagnosis of colorectal cancer may not benefit from this research.
What this research studies
This research investigates the role of Oncofetal Stem Cells (OnFSCs) in colorectal cancer (CRC), a leading cause of cancer-related deaths. It aims to explore how these cells, alongside traditional stem cells, contribute to tumor growth and resistance to treatment. By analyzing the molecular characteristics and functions of these cells, the research seeks to uncover new therapeutic targets that could improve treatment outcomes for CRC patients. The study employs advanced techniques to characterize these stem cells at a functional and molecular level.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that effectively target colorectal cancer and reduce recurrence rates.
How similar studies have gone: While the existence of Oncofetal Stem Cells has been suggested in preliminary studies, this research aims to provide deeper insights into their role, making it a novel exploration in the field.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mzoughi, Slim — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mzoughi, Slim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.