Understanding small vessel disease and its role in Alzheimer's and related dementias
VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD
This study is looking into how small blood vessel problems in the brain can lead to dementia, like Alzheimer's, by examining brain samples and using advanced imaging techniques to better understand the changes that happen as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11022118 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind small vessel cerebrovascular disease (CSVD) and its contributions to dementia, particularly Alzheimer's disease and related disorders. By utilizing advanced technologies, the study aims to analyze thousands of proteins and metabolites in cerebrospinal fluid and human brain tissue samples. The research will also employ neuroimaging techniques to identify specific patterns of white matter hyperintensities, which are crucial for understanding the pathology of these diseases. The goal is to uncover the complex interactions that lead to cognitive decline in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those with symptoms of cognitive decline.
Not a fit: Patients with non-cerebrovascular related forms of dementia or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in understanding cerebrovascular contributions to dementia, indicating that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lee, Jin-Moo — Washington University
- Study coordinator: Lee, Jin-Moo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.