Understanding small RNAs in acute lung injury
Role of tRNA- and rRNA-derived RNAs in acute lung injury
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-11181153
This project explores tiny genetic molecules called small non-coding RNAs to better understand the severe inflammation seen in acute lung injury.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11181153 on ClinicalTrials.gov |
What this research studies
Acute lung injury (ALI) is a serious breathing problem with high mortality, often caused by uncontrolled inflammation in the lungs. Currently, there are no effective treatments for ALI, and we need more information about the specific molecules that drive this inflammation. This project focuses on newly discovered types of small non-coding RNAs, which are tiny genetic pieces that play important roles in many body processes and diseases. By learning more about how these small RNAs contribute to inflammation in ALI, we hope to uncover new ways to help patients.
Who could benefit from this research
Good fit: Patients experiencing acute lung injury or those at risk for it could potentially benefit from future treatments developed from this foundational understanding.
Not a fit: Patients without acute lung injury or related inflammatory lung conditions would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose acute lung injury earlier or develop new treatments that target the specific molecules causing inflammation.
How similar studies have performed: While microRNAs have been studied in ALI, the specific types of small non-coding RNAs being investigated here are largely uncharacterized, making this a novel approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIRINO, YOHEI — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: KIRINO, YOHEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury