Understanding sleep problems in Parkinson's disease using brain recordings and stimulation
Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain Stimulation
This study is looking at how sleep problems affect people with Parkinson's disease by checking the brain's activity while they sleep, and it hopes to find ways to help improve their sleep and health by using new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11065427 on NIH RePORTER |
What this research studies
This research investigates how sleep dysfunction affects individuals with Parkinson's disease by examining the brain's signals and circuits during sleep. Using advanced techniques like chronic intracranial recordings and closed-loop Deep Brain Stimulation (DBS), the study aims to identify the specific brain structures that disrupt normal sleep patterns. By understanding these disruptions, the research seeks to develop targeted therapies that could improve sleep quality and overall health for patients. Participants will be monitored in their own homes, allowing for a more natural observation of their sleep patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience sleep disturbances.
Not a fit: Patients without Parkinson's disease or those who do not experience sleep dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve sleep quality and reduce symptoms in patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promise in using neuromodulation techniques for treating sleep disorders, indicating potential success for this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Little, Simon — University of California, San Francisco
- Study coordinator: Little, Simon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.