Understanding skull defects in Marfan syndrome
Official title: Characterization of calvarial defects in Marfan syndrome models
Funded at New York University · NIH-10869053 · Data updated 2026-11-12
This study is looking at how a condition called craniosynostosis, which affects skull shape, happens in kids with Marfan syndrome, and it aims to find better ways to help them without needing surgery by understanding the role of a special protein in their growth.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $161,000 |
| NIH project number | 1R03HD114829-01 |
| Project ID | NIH-10869053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Marfan syndrome who exhibit craniosynostosis or related skull defects.
✕Less likely to help
Patients without craniosynostosis or those who do not have Marfan syndrome may not benefit from this research.
What this research studies
This research investigates how defects in the skull, specifically craniosynostosis, occur in models of Marfan syndrome. It focuses on the role of a specific protein, fibrillin-1, which is crucial for the development of connective tissues and may influence skull growth. By studying these defects, the research aims to improve current treatment methods that often involve invasive surgeries for affected children. The approach includes examining the biological mechanisms behind these defects to find better intervention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for children with craniosynostosis, reducing the need for multiple surgeries and associated complications.
How similar studies have gone: While craniosynostosis has been studied in various contexts, the specific focus on Marfan syndrome and its connection to skull defects is relatively novel and has not been extensively researched.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Jeong, Juhee — New York University
- Study coordinator: Jeong, Juhee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.