Understanding Skin Cell Signals
Epidermal Signaling Regulators
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11124844
This project explores how signals inside our skin cells help them grow and function properly, and how these signals might contribute to diseases like cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11124844 on ClinicalTrials.gov |
What this research studies
This project aims to understand the complex communication systems within our skin cells, specifically focusing on how certain proteins called GPCRs and ADCRs control gene activity. Researchers are building on previous work that identified key roles for specific proteins, like ADGRL2, in guiding how skin cells develop and mature. They plan to uncover the exact steps and interactions that allow these proteins to send signals that promote healthy skin cell differentiation. By using genetic methods, the team will test how these signaling pathways work in skin tissue. The ultimate goal is to gain a deeper understanding of these fundamental processes, which are crucial for maintaining healthy skin and preventing disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work may seek patients with specific skin conditions or cancers.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: Understanding these fundamental cellular processes could lead to new ways to prevent or treat skin diseases, including certain cancers.
How similar studies have performed: Previous work by this research group has successfully identified key signaling proteins involved in skin cell differentiation, providing a strong foundation for this continued investigation.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHAVARI, PAUL — STANFORD UNIVERSITY
- Study coordinator: KHAVARI, PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers