Understanding skeletal stem cells in craniofacial bone conditions
Skeletal stem cell plasticity in craniofacial bone diseases.
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11195654
This work explores how stem cells in the face and skull bones change, aiming to better understand and help people with craniofacial bone diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11195654 on ClinicalTrials.gov |
What this research studies
Our craniofacial bones are constantly working for activities like chewing and breathing, yet they don't heal as well as other bones. This project looks into how stem cells in these bones adapt and form new bone, which is a key part of how our faces and skulls develop and respond to daily demands. By focusing on these stem cells, we hope to uncover the basic reasons behind common craniofacial bone diseases that dentists and doctors see. This knowledge could lead to new ways to help patients with these challenging conditions.
Who could benefit from this research
Good fit: Patients with various craniofacial bone diseases, particularly those involving bone formation or regeneration issues, could eventually benefit from this research.
Not a fit: Patients whose conditions are unrelated to skeletal stem cell function or craniofacial bone development may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of craniofacial bone diseases, potentially leading to new treatments or improved care for patients.
How similar studies have performed: While significant progress has been made in understanding congenital craniofacial deformities, this specific focus on dynamic stem cell regulation in later life for common diseases represents a fundamental knowledge gap.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONO, NORIAKI — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: ONO, NORIAKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases