Understanding signals that lead to liver cancer development
Intra- and inter-cellular signals that drive hepato-oncogenesis
This study is looking at how certain molecules can sometimes help or hurt liver cancer, and by using mice, researchers hope to learn more about how these molecules affect liver tumors, which could lead to better treatments for people with liver cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10772996 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms that drive liver cancer, specifically hepatocellular carcinoma (HCC). It explores how certain molecules, typically known for promoting cancer, can sometimes have the opposite effect. By using mouse models, the researchers aim to understand how the absence of specific oncogenic molecules influences the development of liver tumors. This study could provide insights into new therapeutic strategies for liver cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with hepatocellular carcinoma.
Not a fit: Patients with liver cancer types other than hepatocellular carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for liver cancer, improving outcomes for patients.
How similar studies have performed: Other research has shown promising results in understanding cancer mechanisms, but this approach may offer novel insights into liver cancer specifically.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Feng, Gen-Sheng — University of California, San Diego
- Study coordinator: Feng, Gen-Sheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.