Understanding Sialic Acids in Alzheimer's Disease
Sialoglycoproteomic network and target discovery for Alzheimer's disease
This project aims to better understand how certain sugar molecules called sialic acids contribute to Alzheimer's disease, hoping to find new ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11132958 on NIH RePORTER |
What this research studies
Alzheimer's disease is a challenging condition with no effective treatments, so researchers are looking for new insights into its causes. This project focuses on protein sialylation, a process where sialic acids attach to proteins, which is important for brain function. We want to learn how changes in these sialoglycoproteins might lead to Alzheimer's disease. By exploring this under-studied area, we hope to uncover new disease processes and identify specific targets for earlier diagnosis and future therapies.
Who could benefit from this research
Good fit: This foundational research is for anyone affected by or at risk for Alzheimer's disease, as it seeks to improve future diagnostic and therapeutic options.
Not a fit: Patients will not receive direct, immediate benefit from this basic science project, as it is focused on discovery rather than direct patient intervention.
Why it matters
Potential benefit: If successful, this work could lead to new ways to detect Alzheimer's disease earlier and develop more effective treatments.
How similar studies have performed: While protein sialylation is an under-studied area in Alzheimer's, existing evidence highlights its importance in brain function and its connection to human neurological diseases.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Li, Lian — Emory University
- Study coordinator: Li, Lian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.