Understanding Sex Differences in Sleep Recovery
Sex differences in the ability to recover from sleep loss: the roles of development and sex chromosome dosage
This project explores how biological sex influences our ability to bounce back from not getting enough sleep.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11070350 on NIH RePORTER |
What this research studies
We know that men and women often experience sleep differently, but the reasons are complex. This project looks at how sex chromosomes, like the Y chromosome, might play a role in shaping sleep patterns from early development into adulthood. Researchers are using special mouse models to uncover how these genetic differences affect how well someone recovers after losing sleep. The goal is to understand the fundamental ways our bodies regulate sleep and how these processes are established.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to understand biological mechanisms relevant to adults who experience sleep loss.
Not a fit: Patients seeking immediate clinical treatments for sleep disorders will not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us understand why sleep loss affects people differently based on their sex, potentially leading to more personalized approaches for managing sleep problems.
How similar studies have performed: This project builds upon existing knowledge that gonadal hormones and sex chromosomes influence sleep, but it explores the specific roles of the Sry gene and X chromosome dosage in sleep recovery in a novel way.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Paul, Ketema N — University of California Los Angeles
- Study coordinator: Paul, Ketema N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.