Understanding Sex Differences in Lewy Body Dementias
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body Dementias
This work explores why Lewy body dementia affects men and women differently, looking at genetic factors and brain changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11161631 on NIH RePORTER |
What this research studies
We know that Lewy body dementia often shows up differently in men and women, but we don't fully understand why. This project aims to uncover how genetic risk factors related to Alzheimer's disease might play a bigger role in dementia risk for women with Lewy body dementia, especially since women are more likely to have both conditions. We also want to see if the specific areas of the brain affected by Lewy body and Alzheimer's pathology differ between sexes, which could explain why symptoms vary. Ultimately, this information will help us create better ways to tell Lewy body dementia apart from Alzheimer's disease, especially for women.
Who could benefit from this research
Good fit: This research is most relevant to patients diagnosed with Lewy body dementia or Alzheimer's disease, or those with a family history of these conditions.
Not a fit: Patients without Lewy body dementia or Alzheimer's disease are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate diagnoses and personalized treatment approaches for individuals with Lewy body dementia, considering their sex.
How similar studies have performed: While sex differences in dementia are increasingly recognized, this specific approach to link genetic risk factors and regional brain pathology in Lewy body dementia is a novel area of focus.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bayram, Ece — University of Colorado Denver
- Study coordinator: Bayram, Ece
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.