Understanding Sex Differences in Heart and Metabolic Health
Sex Differences in Cardiometabolic Health and Disease
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11168924
This program explores why heart and metabolic conditions, like obesity and heart failure, affect men and women differently, aiming to improve diagnosis and treatment for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11168924 on ClinicalTrials.gov |
What this research studies
This program looks at how sex, including hormones like estrogen, X and Y chromosomes, and individual genetic differences, influences heart and metabolic health. Researchers are using mouse models, human stem cells, and existing human health data to find these differences. One part focuses on how genes on the X and Y chromosomes might lead to sex differences in obesity and side effects from statin drugs. Another part aims to understand why a specific type of heart failure is more common in women. The goal is to identify factors that determine sex-specific disease risk.
Who could benefit from this research
Good fit: Patients with cardiometabolic diseases, such as obesity or heart failure, who are interested in understanding how sex differences impact their condition, might benefit from future findings.
Not a fit: Patients whose conditions are not related to cardiometabolic health or sex-specific biological differences may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and effective treatments for heart and metabolic diseases, tailored to an individual's sex.
How similar studies have performed: This program builds on previous findings regarding X and Y chromosome genes influencing sex differences in obesity and statin side effects, indicating some prior success in related areas.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REUE, KAREN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: REUE, KAREN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.