Understanding Sex Differences in Heart and Lung Damage After Radiation Exposure
Sex-dependent Impairment of Nitric Oxide Signaling and Mitochondrial Metabolism in Radiation-Induced Cardio-Pulmonary Dysfunction
This project explores why radiation exposure might affect the heart and lungs differently in men and women, aiming to find new ways to protect these vital organs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11094847 on NIH RePORTER |
What this research studies
Radiation exposure, whether from cancer treatment or accidental events, can seriously harm the heart and lungs, leading to conditions like heart failure, arrhythmias, and lung scarring. We know that men and women often react differently to radiation, with women sometimes showing greater susceptibility to long-term toxicities, but the reasons for these differences are not fully understood. This project uses animal models to investigate how specific cellular processes, like nitric oxide signaling and mitochondrial energy production, contribute to these sex-specific patterns of heart and lung damage. By uncovering these underlying mechanisms, we hope to identify new targets for therapies that could prevent or lessen these serious complications.
Who could benefit from this research
Good fit: This foundational work is relevant for cancer patients undergoing radiation therapy to the chest and individuals who have experienced accidental radiation exposure.
Not a fit: Patients without a history of radiation exposure to the chest or those with unrelated heart and lung conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or protective strategies, potentially tailored by sex, to reduce heart and lung damage for individuals exposed to radiation.
How similar studies have performed: While sex differences in radiation response are recognized, this project explores novel mechanisms involving nitric oxide signaling and mitochondrial metabolism to address cardio-pulmonary dysfunction.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: London, Barry — University of Iowa
- Study coordinator: London, Barry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.