Understanding Sex Differences in Autism
Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11145157
This research aims to uncover why autism affects more males than females by looking at how brain chemicals and connections develop differently.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11145157 on ClinicalTrials.gov |
What this research studies
We know that autism is diagnosed more often in males, but we don't fully understand why. This project explores how a brain chemical called serotonin, which is important for social behaviors, develops differently in male and female brains. We are focusing on specific molecules called Neurexins, which help brain cells connect, and are known to be involved in conditions like autism. By studying these differences, we hope to learn more about how autism develops in a sex-specific way.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with autism spectrum disorder, particularly by understanding sex-specific aspects of the condition.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of autism's causes and potentially new, sex-specific approaches for support and treatment in the future.
How similar studies have performed: Previous work has shown that Neurexins are important risk factors for neurodevelopmental disorders and that changes in serotonin and Neurexins in animal models can affect social behaviors.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUTAI, KENSUKE — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: FUTAI, KENSUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder