Understanding severe pneumonia acquired in hospitals
Systems Biology Modeling of Severe Hospital-Acquired Pneumonia
This study is looking at how the body's response to certain bacteria affects patients with severe pneumonia, and it aims to find new ways to predict how well they will do and improve their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11014082 on NIH RePORTER |
What this research studies
This research investigates severe hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) by examining the interplay between the host's inflammatory response, the specific bacteria causing the infection, and the pulmonary microbiome. Patients with pneumonia will be enrolled to provide bronchoalveolar lavage samples, which will be analyzed using advanced multi-omic techniques. The goal is to identify unique biosignatures and microbiome patterns that can predict patient outcomes and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with hospital-acquired pneumonia or ventilator-associated pneumonia.
Not a fit: Patients with pneumonia not acquired in a hospital setting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better outcomes for patients suffering from severe pneumonia.
How similar studies have performed: Previous research has shown promise in using multi-omic approaches to understand complex infections, suggesting potential for success in this novel investigation.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hauser, Alan R — Northwestern University at Chicago
- Study coordinator: Hauser, Alan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.