Understanding severe organ failure in children on life support
Single cell multi-omics approaches in identifying driving cells and genes in pediatric MODS patients requiring ECMO support
This research aims to find better ways to understand and help children in the intensive care unit who experience severe organ failure and need advanced life support.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11163320 on NIH RePORTER |
What this research studies
Many children in the intensive care unit face a serious condition called multiple organ dysfunction syndrome (MODS), especially when they need advanced life support like ECMO. Currently, it's hard to predict when their condition might get worse, and there aren't good ways to diagnose these changes at a molecular level. This project uses advanced techniques to look at individual cells and their genes, along with computer learning, to understand what happens when MODS deteriorates. By studying these tiny details, we hope to uncover the specific cells and genes that drive the worsening of MODS. This deeper understanding could pave the way for new diagnostic tools and treatments to improve outcomes for these vulnerable children.
Who could benefit from this research
Good fit: This research focuses on understanding severe organ failure in pediatric patients who need veno-arterial extracorporeal membrane oxygenation (ECMO) support.
Not a fit: Patients not experiencing multiple organ dysfunction syndrome or not requiring ECMO support would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis and more effective treatments for children with severe organ failure who require advanced life support.
How similar studies have performed: Previous research using less detailed methods has shown promising links between immune responses and organ failure, but this project uses more advanced techniques to gain a deeper understanding.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Shankar, Rama — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Shankar, Rama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.