Understanding serotonin changes after traumatic brain injury
Official title: No REST for 5-HT Neurons Following Traumatic Brain Injury
Funded at University of Cincinnati · NIH-10921350 · Data updated 2026-11-12
This study is looking at how a traumatic brain injury can impact the brain's mood-regulating serotonin neurons, which might help us understand and find better treatments for people dealing with depression and anxiety after such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 3, 2024 |
| Project end | August 1, 2029 |
| Funding year | 2024 |
| Award (this year) | $405,000 |
| NIH project number | 1R01NS137887-01 |
| Project ID | NIH-10921350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are suffering from related mood or anxiety disorders.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or do not have related neuropsychiatric symptoms may not benefit from this research.
What this research studies
This research investigates how traumatic brain injury (TBI) affects serotonin (5-HT) neurons in the brain, which are crucial for regulating mood and behavior. By using a preclinical model, the study aims to uncover the molecular mechanisms behind the neuropsychiatric issues that often follow TBI, such as depression and anxiety. The researchers will analyze changes in serotonin levels and the expression of specific genes related to serotonin neuron function after injury. This could lead to better understanding and potential new treatments for those suffering from TBI-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for neuropsychiatric disorders following traumatic brain injury.
How similar studies have gone: While the specific approach of this research is novel, there have been other studies exploring serotonin's role in neuropsychiatric disorders, indicating potential for success.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Robson, Matthew — University of Cincinnati
- Study coordinator: Robson, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.