Understanding sepsis in Uganda to improve treatment outcomes
Official title: Multidimensional and longitudinal immune profiling of sepsis in Uganda
Funded at Columbia University Health Sciences · NIH-10938759 · Data updated 2026-11-12
This study is looking at how sepsis affects people in Uganda differently than in wealthier countries, especially focusing on how local factors like HIV/AIDS influence the disease, so we can find better ways to treat it and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $615,891 |
| NIH project number | 1R01AI184997-01 |
| Project ID | NIH-10938759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals in Uganda who are experiencing sepsis, particularly those with comorbidities such as HIV/AIDS.
✕Less likely to help
Patients outside of Uganda or those not suffering from sepsis may not benefit from this research.
What this research studies
This research investigates the unique characteristics of sepsis in sub-Saharan Africa, particularly Uganda, where the disease presents differently than in high-income countries. By analyzing immune responses and pathogen profiles, the study aims to identify specific subtypes of sepsis that are influenced by local demographics and the prevalence of HIV/AIDS. The research employs advanced techniques like RNA sequencing and machine learning to develop tailored treatment strategies that could improve patient outcomes. The goal is to create a better understanding of sepsis that can lead to more effective and relevant treatment protocols for patients in this region.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for sepsis patients in Uganda, potentially reducing mortality rates.
How similar studies have gone: While there has been research on sepsis in high-income countries, this approach focusing on the unique context of sub-Saharan Africa is novel and has not been extensively tested.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Cummings, Matthew John — Columbia University Health Sciences
- Study coordinator: Cummings, Matthew John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.