Understanding Sepsis in Children Using Advanced Biology
Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping
This work uses advanced biological techniques to better understand why some children with sepsis get sicker than others, aiming to find new ways to help them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11327912 on NIH RePORTER |
What this research studies
Sepsis is a serious health problem for children, and we currently lack specific treatments beyond antibiotics and organ support. We know that children with sepsis respond differently, and these differences make it hard to find effective therapies. This project will look closely at biological samples from children who have had sepsis to uncover the underlying reasons for these differences. By using advanced 'multi-omics' methods, which examine many biological factors at once, we hope to identify distinct groups of patients. This understanding could lead to more personalized and effective treatments for children with sepsis in the future.
Who could benefit from this research
Good fit: This research focuses on understanding sepsis in children, particularly those who have experienced severe forms of the condition.
Not a fit: Patients who do not have sepsis or are not within the pediatric age range would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of pediatric sepsis, allowing doctors to identify specific patient groups and develop targeted treatments for them.
How similar studies have performed: While gene-expression profiling has been used to identify patient groups, this project takes a more comprehensive 'multi-omics' approach, which is a newer and more integrated strategy.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Atreya, Mihir R — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Atreya, Mihir R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.