Understanding Self-Awareness in Opioid Addiction
Neurocircuitry of clinical insight predicting relapse outcomes in opioid addiction
This project aims to understand how a person's self-awareness about their opioid addiction connects to their ability to stay in treatment and avoid relapse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10868724 on NIH RePORTER |
What this research studies
Many people with opioid addiction may not fully recognize the severity of their illness or their need for ongoing treatment, which can make it harder to stay sober. This project explores how this self-awareness, or "insight," is linked to brain activity. We want to see if understanding a person's insight and brain patterns can help us predict who might struggle with relapse or treatment adherence. The goal is to find new ways to support individuals in their recovery journey by identifying early markers for success or challenges.
Who could benefit from this research
Good fit: Ideal participants are individuals recently detoxified and currently receiving medication for opioid use disorder, primarily those whose primary drug was heroin, as well as healthy volunteers.
Not a fit: Patients who are not currently in treatment for opioid use disorder or who do not meet the specific criteria for recent detoxification and medication maintenance may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify individuals at higher risk of relapse and develop more personalized treatment strategies for opioid use disorder.
How similar studies have performed: This is described as the first systematic investigation of insight and its underlying neural circuitry as predictors of relapse and treatment adherence in opioid use disorder, suggesting a novel approach in this specific area.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Moeller, Scott J — State University New York Stony Brook
- Study coordinator: Moeller, Scott J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.