Understanding seizures and outcomes in children after a stroke
Official title: Seizures and Children's Outcomes after Stroke (SCOUTS)
Funded at University of California, San Francisco · NIH-11004699 · Data updated 2026-11-12
This study is looking at how seizures that happen soon after a stroke in kids might lead to long-term epilepsy and learning difficulties, and it’s for children aged 28 days to 19 years who have had a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $599,378 |
| NIH project number | 5R01NS119896-04 |
| Project ID | NIH-11004699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 28 days to 19 years who have experienced an ischemic stroke.
✕Less likely to help
Patients who have not experienced a stroke or are older than 19 years may not benefit from this research.
What this research studies
This research investigates how seizures that occur shortly after a stroke in children can lead to long-term epilepsy and cognitive challenges. By studying children aged 28 days to 19 years who have experienced a stroke, the research aims to identify the biological mechanisms linking acute seizures to later epilepsy. The study will analyze blood samples to explore inflammatory pathways and brain injury markers that may contribute to these outcomes. The findings could help improve treatment and prevention strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to better management and prevention of epilepsy in children who have suffered a stroke.
How similar studies have gone: Previous research has shown that understanding the relationship between acute seizures and long-term epilepsy can lead to significant advancements in treatment strategies.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Fox, Christine K. — University of California, San Francisco
- Study coordinator: Fox, Christine K.
Related research
Other NIH-funded projects on the same topics.
-
Seizures and long-term outcomes after childhood stroke
This project looks at whether early seizures and inflammation after a childhood stroke are linked to later epilepsy and recovery in kids up to 19 years old.
-
Post-stroke seizure mechanisms and treatments in a mouse model
Researchers are testing new ways to prevent seizures after a stroke using a mouse model and two potential treatments.
-
Seizures after childhood stroke and how they affect recovery
This project examines whether seizures that happen soon after a child's stroke cause more inflammation and raise the chance of developing epilepsy later on.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
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Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.