Understanding seizures after brain injuries
Official title: Acute neural injury and posttraumatic epilepsy
Funded at University of California Riverside · NIH-11110443 · Data updated 2026-11-12
This study is looking at how and why some people develop seizures after a brain injury, aiming to find out which parts of the brain are affected and how they change, so we can improve ways to prevent or treat these seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $549,809 |
| NIH project number | 5R01NS134914-02 |
| Project ID | NIH-11110443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are at risk of developing posttraumatic epilepsy.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or those with pre-existing seizure disorders may not benefit from this research.
What this research studies
This research investigates posttraumatic epilepsy (PTE), which involves chronic seizures that can occur after a traumatic brain injury (TBI). The study aims to identify the specific brain areas where PTE develops and the physiological changes that occur in these regions. By using advanced techniques like multielectrode array electroencephalography (EEG), researchers will analyze the cellular and molecular alterations that contribute to the emergence of seizure foci in the brain. This research could lead to a better understanding of how to prevent or treat seizures following brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from seizures after traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of posttraumatic epilepsy, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Binder, Devin K — University of California Riverside
- Study coordinator: Binder, Devin K
Related research
Other NIH-funded projects on the same topics.
-
Scaling Up Task-Shifted Epilepsy Care for Children in Africa
A study to help children with epilepsy in Africa get diagnosed and receive seizure care through trained community health workers.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Epilepsy Data Ecosystem: A Big-Data Sharing Platform for Better Care
A national effort to collect and share large, multi‑modal brain data from people with medication‑resistant epilepsy to speed discoveries and improve treatment options.
-
Exploring epilepsy genes in zebrafish to understand human brain seizures
A study in zebrafish will model human epilepsy genes to help explain how certain brain mutations contribute to seizures.
-
New MRI tools to better plan pediatric epilepsy surgery
A new MRI-based approach helps doctors decide the best time to surgically remove brain tissue in children with difficult-to-control seizures.
-
Sahel Epilepsy Study: finding patterns in epilepsy in rural Africa and its links to genes
A plan to study epilepsy in rural Nigeria to discover how common it is, what factors affect risk, and how genetics may influence it, with results that could improve care for people with epilepsy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.