Understanding Sarcoma's Surroundings to Find New Treatments
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11031359
This work creates new models to better understand aggressive soft-tissue sarcomas and find new ways to help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11031359 on ClinicalTrials.gov |
What this research studies
Soft-tissue sarcomas are complex cancers that affect many adults each year, and current treatments like chemotherapy and radiation often have limited success for the most aggressive types. This project aims to build better models, specifically mouse models, that closely match the genetic changes seen in patients' tumors. By studying these advanced models, we hope to learn more about how the tumor's environment helps it grow and resist treatment. This deeper understanding could lead to the discovery of new markers for the disease and new treatment options, especially immune-based therapies, for patients with these challenging sarcomas.
Who could benefit from this research
Good fit: This foundational research is focused on understanding aggressive soft-tissue sarcomas, particularly those with complex genetic changes, to inform future treatments for adult patients.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation would not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new biomarkers and therapeutic targets, offering new treatment strategies for patients with aggressive soft-tissue sarcomas.
How similar studies have performed: While current animal models have limitations, this approach uses novel models designed to more accurately reflect human patient tumors, building on existing knowledge of sarcoma biology.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUARNERIO, JLENIA — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: GUARNERIO, JLENIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.