Understanding RNA to discover new medicines
ncRNA: structure, function and inhibition
This work helps us learn how drug-like molecules interact with RNA, which could lead to new treatments for various diseases, including communicable diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11111377 on NIH RePORTER |
What this research studies
Our bodies contain RNA, which plays many important roles, and sometimes contributes to diseases. This project aims to understand how small, drug-like molecules can specifically attach to RNA. By figuring out these fundamental interactions, we hope to unlock a whole new way to create medicines. This knowledge could help us design powerful new drugs that target RNA to treat conditions that currently lack good options.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but its future impact is intended for individuals affected by diseases that could be treated by targeting RNA, such as communicable diseases.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not find a direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of entirely new types of drugs for a wide range of diseases, including those caused by infections.
How similar studies have performed: This project builds on prior breakthroughs by the team, which have already led to the discovery of drug-like molecules that bind to RNA and have resulted in academic publications and a spin-off company.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Varani, Gabriele — University of Washington
- Study coordinator: Varani, Gabriele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.