Understanding RNA structures and their functions in living cells
High Throughput Determination of RNA 3D Structures and Dynamics in Vivo
This study is exploring how the shapes of RNA affect how genes work and how RNA viruses behave, with the goal of finding better ways to treat diseases by improving our understanding of RNA in living cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10898907 on NIH RePORTER |
What this research studies
This research focuses on the complex roles of RNA in biology, particularly how its three-dimensional structures influence gene expression and the life cycles of RNA viruses. By developing innovative methods to analyze RNA structures in living cells, the project aims to overcome current limitations in RNA structure analysis that have hindered therapeutic advancements. The approach combines advanced chemical probing techniques with computational modeling to provide insights into RNA dynamics and functionality. This could lead to new strategies for targeting RNA in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diseases linked to RNA dysfunction, such as certain viral infections or genetic disorders.
Not a fit: Patients with conditions unrelated to RNA biology or those who do not have RNA-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in RNA-targeted therapies for a range of human diseases.
How similar studies have performed: Other research has shown promise in RNA-targeted therapies, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lu, Zhipeng — University of Southern California
- Study coordinator: Lu, Zhipeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.