Understanding RNA modifications in complex tissues
Dissecting epitranscriptomic signal from complex tissues
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10928118
This study is looking at how changes in RNA can influence gene activity, especially in brain-related diseases, and it’s for anyone interested in understanding more about how these changes might affect health and illness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10928118 on ClinicalTrials.gov |
What this research studies
This research investigates how RNA modifications affect gene expression, particularly in the context of neurological diseases. By utilizing a technique called Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq), the researchers aim to profile RNA epigenetic modifications across different tissues. They will develop new statistical methods to analyze the data, addressing challenges such as technical artifacts and tissue sample heterogeneity. This work could lead to better insights into the role of RNA modifications in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in the genetic basis of brain function.
Not a fit: Patients with non-neurological conditions or those not affected by gene expression-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation in neurological diseases, potentially leading to new therapeutic strategies.
How similar studies have performed: Other research in RNA epigenetics has shown promising results, indicating that this approach could lead to significant advancements in understanding gene regulation.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, ZHIJIN JEAN — BROWN UNIVERSITY
- Study coordinator: WU, ZHIJIN JEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.