Understanding RNA from retrotransposable elements in Alzheimer's disease
Regulation and function of dsRNAs derived from retrotransposable elements in AD
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11089586
This study is looking at how certain RNA molecules in the brain might affect the development of Alzheimer's disease, with the hope that understanding these molecules could lead to new ways to help people with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11089586 on ClinicalTrials.gov |
What this research studies
This research investigates how double-stranded RNAs (dsRNAs) derived from retrotransposable elements (RTEs) may influence the development and progression of Alzheimer's disease (AD). The study focuses on the regulation and function of these RNAs, which are prevalent in the human brain and may play a role in neurodegenerative processes. By analyzing the expression of RTE-derived RNAs and their potential impact on neuronal health, the research aims to uncover new mechanisms that contribute to AD pathology. Patients may benefit from insights gained into how these RNAs affect disease progression and could lead to novel therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into the mechanisms of Alzheimer's disease and potentially lead to innovative treatment approaches.
How similar studies have performed: While the specific focus on RTE-derived RNAs in Alzheimer's is novel, related research has shown promising results in understanding the role of RNA in neurodegenerative diseases.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAO, XINSHU GRACE — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: XIAO, XINSHU GRACE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease brain, Alzheimer's disease model