Understanding RNA from integrated hepatitis B virus DNA
Characterization of 5'-human-HBV-3' RNA species transcribed from integrated HBV DNA
['FUNDING_R21'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11017777
This study is looking at how the hepatitis B virus affects your body by examining special RNA produced from the virus in people with chronic hepatitis B, hoping to find new ways to understand and treat the infection and its possible link to liver cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11017777 on ClinicalTrials.gov |
What this research studies
This research investigates the unique RNA species produced from the integrated DNA of the hepatitis B virus (HBV) in patients with chronic HBV infection. By analyzing liver tissues and blood samples from individuals infected with HBV, the study aims to uncover the mechanisms of HBV pathogenesis and how these RNA species may influence disease progression. The researchers will utilize advanced long-read RNA sequencing techniques to characterize these RNA molecules and their potential roles in chronic hepatitis B and liver cancer. This work could lead to new insights into HBV infection and inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic hepatitis B virus infection.
Not a fit: Patients who are not infected with hepatitis B virus or those who have cleared the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with chronic hepatitis B infection.
How similar studies have performed: While the specific focus on these RNA species is novel, previous research has shown success in understanding HBV pathogenesis and its implications for treatment.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUDIMA, SEVERIN O — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: GUDIMA, SEVERIN O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.