Understanding RNA from integrated hepatitis B virus DNA
Official title: Characterization of 5'-human-HBV-3' RNA species transcribed from integrated HBV DNA
Funded at University of Kansas Medical Center · NIH-11017777 · Data updated 2026-11-12
This study is looking at how the hepatitis B virus affects your body by examining special RNA produced from the virus in people with chronic hepatitis B, hoping to find new ways to understand and treat the infection and its possible link to liver cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $225,525 |
| NIH project number | 5R21AI182029-02 |
| Project ID | NIH-11017777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic hepatitis B virus infection.
✕Less likely to help
Patients who are not infected with hepatitis B virus or those who have cleared the infection may not benefit from this research.
What this research studies
This research investigates the unique RNA species produced from the integrated DNA of the hepatitis B virus (HBV) in patients with chronic HBV infection. By analyzing liver tissues and blood samples from individuals infected with HBV, the study aims to uncover the mechanisms of HBV pathogenesis and how these RNA species may influence disease progression. The researchers will utilize advanced long-read RNA sequencing techniques to characterize these RNA molecules and their potential roles in chronic hepatitis B and liver cancer. This work could lead to new insights into HBV infection and inform future therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with chronic hepatitis B infection.
How similar studies have gone: While the specific focus on these RNA species is novel, previous research has shown success in understanding HBV pathogenesis and its implications for treatment.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Gudima, Severin O — University of Kansas Medical Center
- Study coordinator: Gudima, Severin O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.