Understanding RNA Damage and How Our Bodies Fix It
Biology of RNA damage and repair
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-11092301
This project explores how our cells recognize and repair damage to RNA, a vital molecule similar to DNA, to keep our bodies healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11092301 on ClinicalTrials.gov |
What this research studies
Our bodies have amazing ways to fix damage to DNA, which carries our genetic instructions. This project looks at RNA, another important molecule, which can also get damaged. We want to understand how cells detect and repair this RNA damage, similar to how they fix DNA. Researchers are focusing on specific questions like how certain enzymes affect RNA and how RNA repair systems work in both human cells and bacteria. This knowledge could help us understand how our bodies maintain healthy RNA and what happens when these repair systems don't work correctly.
Who could benefit from this research
Good fit: Patients with conditions related to DNA injury or genetic disorders might find this foundational research relevant to their health.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human trial would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how RNA damage contributes to diseases and potentially identify new targets for therapies.
How similar studies have performed: While DNA repair is well-understood, the mechanisms of RNA damage and repair are less known, making this a novel area of exploration.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HESSELBERTH, JAY R — UNIVERSITY OF COLORADO DENVER
- Study coordinator: HESSELBERTH, JAY R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: DNA Injury, Disease, Disorder