Understanding RNA Changes in Our Cells
Uncovering the regulatory principles of dynamic mRNA methylation
This research explores how tiny chemical changes on RNA molecules inside our cells help control how our genes work, especially in conditions like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11138587 on NIH RePORTER |
What this research studies
Our cells rely on RNA to carry instructions from our DNA, and small chemical tags on RNA can change these instructions, affecting how our bodies function. While we know some of these tags are important for health and disease, many remain a mystery. This project aims to uncover how these RNA tags are regulated and what they do, focusing on a newly discovered tag called m1A. By understanding these fundamental processes, we hope to learn more about how diseases like cancer develop.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications could benefit patients with various cancers.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how gene expression is controlled, potentially opening new avenues for diagnosing and treating diseases, including various cancers.
How similar studies have performed: While the field of RNA modification is rapidly growing, this project addresses novel aspects and technical challenges in understanding specific new modifications and their regulatory mechanisms.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Nachtergaele, Sigrid H — Yale University
- Study coordinator: Nachtergaele, Sigrid H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.