Understanding RNA Changes in Heart and Metabolic Health
RNA modification in cardiometabolic disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11103330
This research explores how tiny chemical changes to RNA, a molecule in our cells, might contribute to serious conditions like heart disease, obesity, and fatty liver disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11103330 on ClinicalTrials.gov |
What this research studies
Our bodies rely on precise control of genes to stay healthy, especially when it comes to how we process food and energy. This project focuses on a specific type of chemical change to RNA, called m6A modification, and how it might affect our metabolism. We've observed that diet can alter these RNA changes in the liver, which then influences how the liver produces and stores fats. By understanding these fundamental processes, we aim to uncover new ways to address conditions such as fatty liver disease, obesity, and cardiovascular disease.
Who could benefit from this research
Good fit: This foundational research focuses on understanding disease mechanisms and does not currently involve direct patient participation.
Not a fit: Patients seeking immediate therapeutic interventions would not directly benefit from this early-stage mechanistic research.
Why it matters
Potential benefit: Successfully understanding these RNA modifications could lead to the development of new strategies and treatments for cardiovascular disease, obesity, and fatty liver disease.
How similar studies have performed: While the general concept of RNA modifications is established, their specific and detailed role in metabolic control and cardiometabolic diseases is a relatively new and active area of investigation.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SALLAM, TAMER — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SALLAM, TAMER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.