Understanding risks and outcomes of blood clots in young patients
Official title: Mentorship in Investigating Novel Risk Models and Prognostic Factors in Patients Less Than 21 Years Old with Venous Thromboembolism
Funded at Johns Hopkins University · NIH-11036368 · Data updated 2026-11-12
This study is looking at blood clots in young people under 21 to find better ways to predict how they will do and improve their treatment, all while helping new researchers learn more about this important health issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $128,052 |
| NIH project number | 5K24HL166791-02 |
| Project ID | NIH-11036368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients under 21 years old who have experienced venous thromboembolism or are at risk for developing this condition.
✕Less likely to help
Patients over 21 years old or those without a history of venous thromboembolism may not benefit from this research.
What this research studies
This research focuses on venous thromboembolism (VTE), a condition where blood clots form in veins, affecting patients under 21 years old. The study aims to develop and validate specific risk assessment models and identify prognostic factors that can help predict outcomes for these young patients. By mentoring junior researchers, the project seeks to enhance knowledge and improve treatment strategies for VTE, which can lead to serious complications like chronic venous insufficiency. The approach includes analyzing existing data and collaborating with international experts to fill critical knowledge gaps in this area.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for blood clots in young patients, ultimately improving their health outcomes.
How similar studies have gone: Previous research has shown success in developing risk assessment models for pediatric VTE, indicating that this approach has potential for further advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Goldenberg, Neil a — Johns Hopkins University
- Study coordinator: Goldenberg, Neil a
Related research
Other NIH-funded projects on the same topics.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large study will test whether taking rosuvastatin every day for a year can lower the chance of dangerous blood clots in people with cancer, without raising the risk of bleeding.
-
Optimal use of blood thinners for venous clots in people with cirrhosis
This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.
-
PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
-
BCOR's role in blood clot risk and liver genetics
A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
-
Personalized risk-prediction for hospital-acquired blood clots in adults
A real-time risk model helps doctors identify adults in the hospital who are at higher risk of developing blood clots so they can prevent them safely.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.