Understanding Right Heart Failure in Pulmonary Hypertension
Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertension
This project looks for new ways to treat right heart failure, a serious problem for people with pulmonary hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11145621 on NIH RePORTER |
What this research studies
Right heart failure is a major concern for individuals living with pulmonary hypertension, often leading to severe health issues. Current treatments for pulmonary hypertension don't directly address the failing right side of the heart. This project aims to uncover the specific changes happening in the right heart muscle that cause it to weaken and scar. By understanding these changes at a molecular level, we hope to discover new targets for medications that could directly help the failing right heart.
Who could benefit from this research
Good fit: Patients who experience right ventricular failure as a complication of pulmonary hypertension are the focus of this research.
Not a fit: Patients without pulmonary hypertension or right ventricular failure would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new treatments specifically designed to protect and improve the function of the right heart in patients with pulmonary hypertension.
How similar studies have performed: While current therapies for pulmonary hypertension exist, this approach to directly target the failing right ventricle through specific molecular pathways is novel and largely untested.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Umar, Soban — University of California Los Angeles
- Study coordinator: Umar, Soban
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.