Understanding respiratory flare-ups in primary ciliary dyskinesia
Characterizing respiratory exacerbations in primary ciliary dyskinesia
This study is looking at why people with primary ciliary dyskinesia (PCD) often have sudden worsening of their breathing problems, and it aims to find out how viruses and bacteria might be involved, so we can come up with better ways to help manage these flare-ups.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10655640 on NIH RePORTER |
What this research studies
This research focuses on primary ciliary dyskinesia (PCD), a rare genetic condition that leads to frequent respiratory infections and inflammation. The study aims to identify the causes of acute respiratory flare-ups, which are characterized by worsening cough, fever, and fatigue. By analyzing samples from patients already enrolled in a larger study, researchers will explore the role of viruses and bacteria in triggering these exacerbations. The goal is to develop better prevention and treatment strategies for managing these episodes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary ciliary dyskinesia who are experiencing respiratory exacerbations.
Not a fit: Patients without a diagnosis of primary ciliary dyskinesia or those who do not experience respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients with primary ciliary dyskinesia, reducing the frequency and severity of respiratory exacerbations.
How similar studies have performed: Previous research has shown promise in understanding respiratory conditions through similar molecular detection approaches, indicating potential for success in this study.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Ferkol, Thomas W — Univ of North Carolina Chapel Hill
- Study coordinator: Ferkol, Thomas W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.