Understanding respiratory flare-ups in primary ciliary dyskinesia
Official title: Characterizing respiratory exacerbations in primary ciliary dyskinesia
Funded at Univ of North Carolina Chapel Hill · NIH-10655640 · Data updated 2026-11-12
This study is looking at why people with primary ciliary dyskinesia (PCD) often have sudden worsening of their breathing problems, and it aims to find out how viruses and bacteria might be involved, so we can come up with better ways to help manage these flare-ups.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $231,393 |
| NIH project number | 5R21TR003860-03 |
| Project ID | NIH-10655640 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary ciliary dyskinesia who are experiencing respiratory exacerbations.
✕Less likely to help
Patients without a diagnosis of primary ciliary dyskinesia or those who do not experience respiratory issues may not benefit from this research.
What this research studies
This research focuses on primary ciliary dyskinesia (PCD), a rare genetic condition that leads to frequent respiratory infections and inflammation. The study aims to identify the causes of acute respiratory flare-ups, which are characterized by worsening cough, fever, and fatigue. By analyzing samples from patients already enrolled in a larger study, researchers will explore the role of viruses and bacteria in triggering these exacerbations. The goal is to develop better prevention and treatment strategies for managing these episodes.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients with primary ciliary dyskinesia, reducing the frequency and severity of respiratory exacerbations.
How similar studies have gone: Previous research has shown promise in understanding respiratory conditions through similar molecular detection approaches, indicating potential for success in this study.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Ferkol, Thomas W — Univ of North Carolina Chapel Hill
- Study coordinator: Ferkol, Thomas W
Related research
Other NIH-funded projects on the same topics.
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Personalized therapeutic oligonucleotides for primary ciliary dyskinesia
A new therapy approach uses customized RNA-based medicines to help people with Primary Ciliary Dyskinesia, a rare lung condition, by correcting how genes are read in airway cells.
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Pathogenesis and New Treatments for Primary Ciliary Dyskinesia (PCD)
Researchers are studying why Primary Ciliary Dyskinesia causes lung and airway problems and how to develop better treatments for people with this condition.
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New genes behind primary ciliary dyskinesia
This project looks for new genes that cause primary ciliary dyskinesia to help people with chronic respiratory infections and related complications.
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How a lung cell protein (cytoglobin) affects cilia movement and organ placement
Researchers are looking at whether the airway protein cytoglobin controls nitric oxide and cilia motion in ways that could explain primary ciliary dyskinesia and situs inversus.
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Understanding and treating Primary Ciliary Dyskinesia
This study is looking at a pig model of Primary Ciliary Dyskinesia (PCD) to better understand how the condition affects breathing and to find new ways to help improve the lives of people living with PCD.
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Finding new genes that cause primary ciliary dyskinesia
This study is looking for new genes that cause primary ciliary dyskinesia (PCD), a condition that affects breathing, to help make faster and cheaper tests for it, using a special model from frog embryos to learn more about how cilia work.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.