Understanding resistance to therapy in pancreatic cancer
Tissue Core-UNMC Rapid Autopsy Program
This study is looking at tissue and blood samples from people with pancreatic cancer to understand why some patients don’t respond to treatment, with the hope of finding better ways to help them in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10926943 on NIH RePORTER |
What this research studies
This research focuses on collecting and analyzing human tissue samples to investigate why some patients with pancreatic ductal adenocarcinoma do not respond to treatment. The program utilizes a Tissue Core that gathers both cancerous and non-cancerous pancreatic tissues, along with blood samples from patients undergoing surgery or from those who have passed away due to pancreatic cancer. By studying these samples, researchers aim to uncover the biological mechanisms behind treatment resistance, which could lead to improved therapies. Patients' clinical data is also collected to correlate with the biological findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing surgical procedures or have a history of this cancer.
Not a fit: Patients with other types of cancer or those not diagnosed with pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for pancreatic cancer patients, improving their chances of survival.
How similar studies have performed: Previous research has shown promise in understanding cancer treatment resistance through similar tissue collection and analysis approaches.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Grandgenett, Paul M — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Grandgenett, Paul M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.