Understanding reduced blood flow in a mouse model of frontotemporal dementia
Investigating the cause of cerebral blood flow reductions in a mouse model of frontotemporal dementia
['FUNDING_R21'] · UNIVERSITY OF MIAMI CORAL GABLES · NIH-10525598
This study is looking at how decreased blood flow in the brain affects people with frontotemporal dementia by using mice to understand what might be causing these changes, so we can learn more about how it impacts brain function.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI CORAL GABLES (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10525598 on ClinicalTrials.gov |
What this research studies
This research investigates how reduced blood flow in the brain affects patients with frontotemporal dementia (FTD) using a mouse model. The study focuses on two mechanisms that may cause these blood flow reductions: capillary stalling and pericyte constriction. By analyzing the microvasculature in these mice, researchers aim to uncover the underlying causes of these phenomena and their impact on brain function. Advanced imaging techniques will be employed to visualize and measure blood flow in the brain's prefrontal cortex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with frontotemporal dementia or those with genetic predispositions to neurodegenerative diseases.
Not a fit: Patients with other forms of dementia not related to frontotemporal dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of frontotemporal dementia, potentially guiding the development of targeted therapies.
How similar studies have performed: Other research has shown promising results in understanding blood flow dynamics in Alzheimer's disease, suggesting that this approach may yield valuable insights for frontotemporal dementia as well.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI CORAL GABLES — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRACKO, OLIVER — UNIVERSITY OF MIAMI CORAL GABLES
- Study coordinator: BRACKO, OLIVER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease