Understanding recurrence and cognitive effects of depression in older adults
2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)
This study is looking at how changes in the brain might lead to depression coming back in older adults who have felt better, and it aims to find out what might trigger these relapses and how they could affect thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10746011 on NIH RePORTER |
What this research studies
This research investigates how neurobiological factors contribute to the recurrence of depression in older adults, particularly after they have achieved remission. It focuses on understanding the relationship between brain network stability and the risk of depressive episodes returning, as well as the impact on cognitive function. By examining these factors, the study aims to identify potential triggers for recurrence and how they relate to cognitive decline in late-life depression. Patients may undergo assessments that evaluate their brain function and mental health history to better understand their individual risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced major depressive episodes and are currently in remission but may be at risk for recurrence.
Not a fit: Patients who have not experienced depression or those with acute depressive episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing recurrence of depression and enhancing cognitive health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological underpinnings of depression recurrence, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Andreescu, Carmen — University of Pittsburgh at Pittsburgh
- Study coordinator: Andreescu, Carmen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.