Understanding recovery pathways of the urethral sphincter and a new treatment approach
Pathways underlying recovery of injured urethral sphincter and a novel regenerative biomaterial intervention
This study is looking at how childbirth can affect the muscles that help control urination in women and aims to create a new material that could help these muscles heal better after injury, making it easier for women to manage stress urinary incontinence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10839447 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the recovery of the urethral sphincter after injury, particularly focusing on how childbirth can lead to stress urinary incontinence in women. The team aims to develop a novel regenerative biomaterial that could enhance recovery and restore function. By using a relevant animal model, the research seeks to uncover the biological processes involved in sphincter dysfunction and explore innovative treatment options that directly address the underlying causes of this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced childbirth and are suffering from stress urinary incontinence.
Not a fit: Patients who have not experienced childbirth or do not have stress urinary incontinence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women suffering from stress urinary incontinence, enhancing their quality of life.
How similar studies have performed: Previous research has shown promise in similar approaches to treating urinary incontinence, but this specific biomaterial intervention is novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Alperin, Marianna — University of California, San Diego
- Study coordinator: Alperin, Marianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.