NIH-funded research R01 grant

Understanding recovery of consciousness after brain hemorrhage

Official title: RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGe

Funded at Columbia University Health Sciences · NIH-10604349 · Data updated 2026-11-12

This study is looking at how people who have had a brain hemorrhage and show signs of being aware can recover their consciousness, using a simple brain test to help understand their progress and find better ways to support their recovery.

More Hemorrhage research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences
NIH-funded
Lab location1 site (New York, United States)
Project startJune 15, 2019
Project endMarch 31, 2026
Funding year2023
Award (this year)$616,022
NIH project number5R01NS106014-05
Project IDNIH-10604349 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients who have experienced an acute brain hemorrhage and are currently in a state of unconsciousness.

Less likely to help

Patients who have not experienced a brain hemorrhage or those who are already conscious and functioning may not benefit from this research.

What this research studies

This research investigates how patients recover consciousness following a brain hemorrhage, a type of acute brain injury. It focuses on a specific group of patients who show signs of cognitive motor dissociation (CMD), where they can respond to commands despite appearing unconscious. By using a bedside EEG test to measure brain activity, the study aims to track the recovery trajectory of these patients over time. The goal is to improve prognostication and develop better treatment strategies for those affected by brain injuries.

Why it matters

Potential benefit: If successful, this research could lead to improved recovery outcomes and better quality of life for patients who have suffered a brain hemorrhage.

How similar studies have gone: Previous studies have shown promising results in understanding cognitive motor dissociation and its implications for recovery, indicating that this approach has potential for success.

Where this research is happening

  • Columbia University Health Sciences
    New York, United States
    Active

Researchers

  • Principal investigator: Claassen, Jan — Columbia University Health Sciences
  • Study coordinator: Claassen, Jan

Related research

Other NIH-funded projects on the same topics.

  • Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease

    This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.

    NIH research Yale University · New Haven, United States · NIH-11533213

  • Statin use after lobar intracerebral hemorrhage

    This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11518526

  • Statin use after lobar brain hemorrhage

    This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11518525

  • Blocking red blood cell death after brain hemorrhage

    A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.

    NIH research Yale University · New Haven, United States · NIH-11450183

  • Targeting HDAC3 to reduce brain damage after a brain bleed

    This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).

    NIH research Augusta University · Augusta, United States · NIH-11386398

  • Silent brain injuries after brain bleed may predict dementia risk

    A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.

    NIH research Rush University Medical Center · Chicago, United States · NIH-11380839

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.