Understanding RAS in Cancer with New Inhibitors
Probing RAS-mediated Signaling with Monobody Inhibitors
This project is developing new ways to block a protein called RAS, which is often involved in many types of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11139440 on NIH RePORTER |
What this research studies
Cancer is a major health concern, and a protein called RAS plays a big role in about 30% of all cancers. While we've learned a lot about RAS, finding effective treatments has been challenging. This project uses special small proteins called monobodies, similar to antibodies, to find new weaknesses in RAS. These monobodies help us understand how RAS works and how we might stop it from causing cancer.
Who could benefit from this research
Good fit: Patients with cancers linked to RAS mutations, particularly those where current treatments are not fully effective, could potentially benefit from future therapies developed from this research.
Not a fit: Patients whose cancers are not caused by RAS mutations would likely not benefit from therapies directly targeting RAS.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for many types of cancer driven by RAS mutations.
How similar studies have performed: This project pioneers the use of monobody technology to uncover new vulnerabilities in RAS, representing a novel approach to a long-standing challenge.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: O'bryan, John P — Medical University of South Carolina
- Study coordinator: O'bryan, John P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.