Understanding Rare Human Cancers by Comparing Them Across Many Mammals
Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers
This project looks at cancers in many different mammals, including humans, to find new ways to understand and treat rare human cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11140394 on NIH RePORTER |
What this research studies
This project aims to understand why some cancers start and grow, and why some animals might be more resistant to cancer, by looking at tumors from many different mammals, including humans. Researchers will create a large collection of tumor information and use computer tools to find patterns in the genetic makeup of these cancers. By comparing cancers across many species, we hope to uncover new insights into human cancer development and potential treatments. This approach combines high-quality genetic data from hundreds of mammalian species with advanced machine learning to reveal the evolutionary roots of cancer.
Who could benefit from this research
Good fit: Patients with rare human cancers might eventually benefit from the insights gained from this broad comparative approach.
Not a fit: Patients whose cancers are not rare or are already well-understood may not directly benefit from this specific comparative research.
Why it matters
Potential benefit: This work could lead to new discoveries about how human cancers develop and new ideas for treating rare human cancers by learning from the natural world.
How similar studies have performed: While comparative oncology is an established field, this project's large-scale, pan-mammalian approach with advanced machine learning is a novel and largely untested strategy.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Graim, Kiley — University of Florida
- Study coordinator: Graim, Kiley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.