Understanding Rapidly Progressive Dementia
Bio-RaPID: Biomarkers and Rates of Progression In Dementia.
This project aims to find biological clues that explain why some forms of Alzheimer's and related dementias progress very quickly in patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11187145 on NIH RePORTER |
What this research studies
Patients with rapidly progressive dementia (RPD) experience very fast declines in thinking abilities, often leading to severe impairment within one to two years. While some RPD cases are due to Creutzfeldt-Jakob disease, many are fast-progressing Alzheimer's or related dementias (rpAD/ADRD). This project, called Bio-RaPID, will work with 120 patients who have rpAD/ADRD to understand the biological reasons behind this rapid decline. We will conduct clinical check-ups and collect blood samples over 24 months, using both in-person visits and remote telemedicine appointments to make it easier for participants. By combining expert clinical care, advanced diagnostic methods, and genetic sequencing, we hope to uncover key factors influencing how quickly these conditions worsen.
Who could benefit from this research
Good fit: Ideal candidates are older individuals experiencing rapidly progressive forms of Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia or those not experiencing rapid decline may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify and potentially treat rapidly progressive forms of Alzheimer's and related dementias.
How similar studies have performed: While rapidly progressive dementias are known, this project takes a novel approach by specifically focusing on the biological factors driving rapid progression in Alzheimer's and related dementias.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Day, Gregory Scott — Mayo Clinic Jacksonville
- Study coordinator: Day, Gregory Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.