Understanding RAF Kinases in Cancer
Chemical biological analysis of RAF Kinases
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11143237
This work explores how certain proteins called RAF Kinases behave in cancer cells to find new ways to target them with medicines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11143237 on ClinicalTrials.gov |
What this research studies
Our bodies have proteins called RAF Kinases that play a big role in how cancer cells grow and spread. Even though we have medicines that target these proteins, we don't fully understand how they work or why some cancers become resistant. This project aims to look closely at how different types of RAF Kinases interact and respond to existing and new treatments. We will use advanced lab techniques to map out their functions and identify what makes them sensitive or resistant to therapies, hoping to guide future drug development.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical trials stemming from this work would likely target patients with cancers driven by specific RAS/RAF mutations.
Not a fit: Patients whose cancers are not related to RAF Kinase activity or RAS mutations would likely not benefit from treatments developed based on this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective treatments for cancers driven by specific genetic changes in RAS and RAF proteins.
How similar studies have performed: While RAF Kinases are a known target in cancer, this project uses novel biochemical and RNA barcoding methods to systematically understand their regulation and drug response in a new way.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MALY, DUSTIN J — UNIVERSITY OF WASHINGTON
- Study coordinator: MALY, DUSTIN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers