Understanding pulmonary vascular disease in children with congenital heart disease
Administrative Core
This study is looking at how lung problems can develop in kids with heart defects because of extra blood flow and pressure, and it aims to find ways to help improve their health by understanding the changes that happen in their lungs.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10922690 on NIH RePORTER |
What this research studies
This research investigates how pulmonary vascular disease (PVD) develops in children with congenital heart disease (CHD) due to increased blood flow and pressure in the lungs. It focuses on the structural and functional changes in the pulmonary vasculature that occur as a result of these conditions. By studying a specific model, researchers aim to understand the metabolic changes that contribute to early pulmonary vascular injury and how these changes affect cell behavior. The goal is to identify potential therapeutic targets to improve outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with congenital heart disease and exhibit signs of pulmonary vascular disease.
Not a fit: Patients with congenital heart disease who do not show signs of pulmonary vascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung health and overall outcomes for children with congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding pulmonary vascular responses in similar conditions, indicating that this approach has potential for success.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.