Understanding PTSD in World Trade Center Responders through DNA Changes
Methylome profile of World Trade Center related PTSD
['FUNDING_U01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11074015
This research looks at changes in DNA from blood samples to better understand why some World Trade Center responders developed PTSD.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11074015 on ClinicalTrials.gov |
What this research studies
Many World Trade Center responders experienced long-lasting psychological trauma, with some developing PTSD even decades later. This project explores how changes in DNA, specifically called DNA methylation, might explain why some individuals are more affected. By studying these genetic markers in stored blood samples, we hope to uncover biological insights into the causes and persistence of PTSD. The goal is to identify unique patterns that could serve as early warning signs or help guide future treatments for PTSD.
Who could benefit from this research
Good fit: This research focuses on existing biobanked blood samples from World Trade Center responders who experienced PTSD.
Not a fit: Patients not directly involved as World Trade Center responders or those without PTSD may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at risk for PTSD or develop more targeted treatments for those affected.
How similar studies have performed: While previous studies have explored similar genetic markers for PTSD, this project uses a more powerful design and will combine data with larger efforts to enhance findings.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUAN, PEI-FEN — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: KUAN, PEI-FEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.