Understanding PTPRS in Rheumatoid Arthritis
Role of PTPRS in Rheumatoid Arthritis
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11124816
This work explores how a protein called PTPRS contributes to rheumatoid arthritis, hoping to find new ways to help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11124816 on ClinicalTrials.gov |
What this research studies
In rheumatoid arthritis, special cells in the joints called fibroblast-like synoviocytes (FLS) cause inflammation and damage. This project aims to understand how a specific protein, PTPRS, works within these FLS cells and how it is controlled. Researchers have found that PTPRS makes FLS more aggressive, and they've developed a way to change PTPRS's function using a special decoy fragment. This decoy has shown promise in reducing arthritis in animal models, suggesting a new path for treatment.
Who could benefit from this research
Good fit: This foundational work is for future patients living with rheumatoid arthritis who might benefit from new, targeted therapies.
Not a fit: Patients without rheumatoid arthritis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that specifically target joint-damaging cells in rheumatoid arthritis, potentially offering a different approach to treatment.
How similar studies have performed: Previous work in this grant's first phase successfully identified PTPRS as a key regulator of FLS aggressiveness and developed an approach to modulate its function.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOTTINI, NUNZIO — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: BOTTINI, NUNZIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.